منابع مشابه
Crawling cells feel the squeeze
Y ou drive differently on narrow streets than you do on an open stretch of highway. Similarly, migrating cells rely on different movement mechanisms depending on whether they have ample space or are in cramped conditions, Hung et al. reveal (1). In the body, migrating cells usually must slither through spaces in the extracellular matrix or slip through narrow channels that run between connectiv...
متن کاملDead cells get the squeeze
acrophages can clean up the detritus of dying cells. But that, say Jody Rosenblatt, Martin Raff, and Louise Cramer (University College London, London, UK), is not the whole story. They have found that cells undergoing apoptosis in an epithelial sheet signal to their neighbors to begin squeezing, in a process that maintains the barrier function of the epithelium while extruding the dying cell. M...
متن کاملOn the crawling of cells.
Motile cells moving in vitro do so via a characteristic motile appendage, the lamellipod, a broad, flat region of the cell cytoplasm which extends ahead of the moving cell, and which is devoid of organelles. I describe here a mechanochemical model for how the lamellipod propels the cell forward. The propulsive force for the spreading of the lamella derives from the swelling pressure of the cyto...
متن کاملBipedal locomotion in crawling cells.
Many complex cellular processes from mitosis to cell motility depend on the ability of the cytoskeleton to generate force. Force-generating systems that act on elastic cytoskeletal elements are prone to oscillating instabilities. In this work, we have measured spontaneous shape and movement oscillations in motile fish epithelial keratocytes. In persistently polarized, fan-shaped cells, retracti...
متن کاملEditorial M ast cells feel the strain *
See article by Huang et al. [1] (pages 150 –160) in this cytokines, prostanoids, platelet activators, vasoactive issue. agents and growth factors [8]. Mast cell activation may also have a role to play in the Mast cells are implicated to be involved in the pathoinitiation and progression of heart disease. Histamine has genesis of atherosclerosis and acute coronary syndromes. been shown to promot...
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 2013
ISSN: 1540-8140,0021-9525
DOI: 10.1083/jcb.2025if